Methamphetamines are an addictive stimulant that are closely related to amphetamine, but have longer lasting and more toxic effects on the central nervous system. Meth has a high potential for abuse and addiction. Meth increases wakefulness and physical activity and decreases your appetite. Chronic, long-term use can lead to psychotic behavior, hallucinations, and even a stroke. Methamphetamines are addictive stimulant drugs that activate certain systems in the brain. They are chemically related to amphetamine but, at comparable doses, the effects of methamphetamines are much more potent, longer lasting, and more harmful to the central nervous system.
Methamphetamines have a high potential for abuse and are available only through a prescription that cannot be refilled. They can be made in small, illegal laboratories, where production endangers the people in the labs, neighbors, and the environment. Meth abusers may become addicted quickly, needing higher doses more often.
What is Crystal Meth?
Crystal Meth is a colorless, odorless form of d-methamphetamine, a powerful and highly addictive synthetic (man-made) stimulant. Crystal Meth typically resembles small fragments of glass or shiny blue-white “rocks” of various sizes. Like powdered Methamphetamine (another form of d-methamphetamine), Crystal Meth is used because of the long-lasting euphoric effects it produces. Crystal Meth, however, typically has a higher purity level and may produce even longer-lasting and more intense physiological effects than the powdered form of the drug.
Crystal Meth is typically smoked using glass pipes and may also be injected. An individual who smokes or injects the drug will immediately experience an intense sensation followed by a high that may last 12 hours or more depending on the dose and how the drug is administered.
How and why is Meth used?
Meth comes in many forms and can be smoked, snorted, injected, or orally ingested. The preferred method of methamphetamine abuse varies by geographical region and has changed over time. Smoking methamphetamine, which leads to very fast uptake of the drug in the brain, has become more common in recent years, amplifying methamphetamine’s addiction potential and adverse health consequences.
The drug also alters mood in different ways, depending on how it is taken. Immediately after smoking the drug or injecting it intravenously, the user experiences an intense rush or “flash” that lasts only a few minutes and is described as extremely pleasurable. Snorting or oral ingestion produces euphoria – a high but not an intense rush. Snorting produces effects within 3 to 5 minutes, and oral ingestion produces effects within 15 to 20 minutes.
As with similar stimulants, meth is typically used in a “binge and crash” pattern. Because the pleasurable effects of meth disappear even before the drug concentration in the blood falls significantly, users try to maintain the high by taking more of the drug. In some cases, abusers indulge in a form of binging known as a “run,” foregoing food and sleep while continuing abuse for up to several days.
What are the signs of using Meth?
• Incessant talking
• Extreme moodiness and irritability
• Repetitious behavior
• Sleep disturbances
• False sense of confidence and power
• Aggressive or violent behavior
• Disinterest in previously enjoyed activities
Is Meth the same as Cocaine?
No; Meth is structurally similar to amphetamine and the neurotransmitter dopamine, but it is quite different from cocaine. Although these stimulants have similar behavioral and physiological effects, there are some major differences in how they work. In contrast to cocaine, which is quickly removed and almost completely metabolized in the body, meth has a much longer duration of action and a larger percentage of the drug remains unchanged in the body. This results in meth being present in the brain longer, which ultimately leads to prolonged stimulant effects. And although both meth and cocaine increase levels of the brain chemical dopamine, animal studies reveal much higher levels of dopamine following administration of meth due to the different mechanisms of action within nerve cells in response to these drugs. Cocaine prolongs dopamine actions in the brain by blocking dopamine re-uptake. While at low doses, meth blocks dopamine re-uptake, meth also increases the release of dopamine, leading to much higher concentrations in the synapse, which can be toxic to nerve terminals.
Man made Plant Derived
Smoking gives a long lasting high Smoking gives a short high
50% of drug is out of the body in 12 hours 50% of drug is out of the body in 1 hour
What are the short-term effects of Meth?
As a powerful stimulant, methamphetamine, even in small doses, can increase wakefulness and physical activity and decrease appetite. Meth can also cause a variety of cardiovascular problems, including rapid heart rate, irregular heartbeat, and increased blood pressure. Hyperthermia (elevated body temperature) and convulsions may occur with methamphetamine overdose, and if not treated immediately, can result in death.
Most of the pleasurable effects of meth are believed to result from the release of very high levels of the neurotransmitter dopamine. Dopamine is involved in motivation, the experience of pleasure, and motor function, and is a common mechanism of action for most drugs of abuse. The elevated release of dopamine produced by meth is also thought to contribute to the drug’s deleterious effects on nerve terminals in the brain.
What are long-term effects of Meth?
Long term meth abuse has many negative consequences, including addiction. Addiction is a chronic, relapsing disease, characterized by compulsive drug seeking and use, accompanied by functional and molecular changes in the brain. In addition to being addicted to meth, chronic abusers exhibit symptoms that can include anxiety, confusion, insomnia, mood disturbances, and violent behavior. They also can display a number of psychotic features, including paranoia, visual and auditory hallucinations, and delusions (for example, the sensation of insects creeping under the skin). Psychotic symptoms can sometimes last for months or years after methamphetamine abuse has ceased, and stress has been shown to precipitate spontaneous recurrence of methamphetamine psychosis in formerly psychotic methamphetamine abusers.
With chronic abuse, tolerance to meth’s pleasurable effects can develop. In an effort to intensify the desired effects, abusers may take higher doses of the drug, take it more frequently, or change their method of drug intake. Withdrawal from methamphetamine occurs when a chronic abuser stops taking the drug. Symptoms of withdrawal include depression, anxiety, fatigue, and an intense craving for the drug.
Chronic methamphetamine abuse also significantly changes the brain. Specifically, brain imaging studies have demonstrated alterations in the activity of the dopamine system that are associated with reduced motor speed and impaired verbal learning. The increased risk of stroke from the abuse of meth can lead to irreversible damage to the brain.
Short Term Long Term
Increased activity and wakefulness Addiction
Decreased appetite Psychosis, including paranoia, hallucinations,
repetitive motor activity
Euphoria and rush Changes in brain structure and function
Increased respiration Memory loss
Rapid/irregular heartbeat Mood disturbances
Severe dental problems
Is treatment effective or necessary to stop using Meth?
Yes; the most effective treatments for meth addiction are behavioral therapies such as cognitive behavioral and contingency management interventions. A comprehensive behavioral treatment approach that combines behavioral therapy, family education, individual counseling, ongoing support, drug testing, and encouragement for non-drug-related activities, has been shown to be effective in reducing methamphetamine abuse.
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Source(s): Center for Addiction and Mental Health, National Institute on Drug Abuse